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KMID : 0811820080120020221
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Journal of Korean Society of Pediatric Nephrology
2008 Volume.12 No. 2 p.221 ~ p.226
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Two Cases of Acute Renal Failure Complicating Paroxysmal Nocturnal Hemoglobinuria in Children
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Rhy Jung-Min
Kang Hyoung-Jin
Shin Hee-Young
Ahn Hyo-Seop
Ha Il-Soo
Cheong Hae-Il
Choi Yong
Choi Hyun-Jin
Lee Beom-Hee
Ahn Yo-Han
Lee So-Hee
Kang Hee-Gyung
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Abstract
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Paroxysmal nocturnal hemoglobinuria(PNH) is an acquired hematologic disorder characterized by intravascular hemolysis, nocturnal hemoglobinuria, thrombotic events and bone marrow failure. It rarely occurs in children and can be complicated by acute renal failure(ARF). Here, we present two cases of ARF complicating PNH which has not been reported yet in Korean children. We suggest that PNH should be considered in differential diagnosis of ARF in children associated with intravascular hemolysis.
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KEYWORD
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Paroxysmal nocturnal hemoglobinuria(PNH), Acute renal failure, Intravascular hemolysis, Children
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